Microcyn HOCl Technology

Microcyn is a stable, highly efficacious pH-neutral wound irrigant based on the science of hypochlorous acid (HOCl). HOCl is a highly efficient, antimicrobial agent that is generated by human cells as a defensive agent.

Antimicrobial Properties

• HOCl, an ingredient in Microcyn, is 70 times more efficacious than the active ingredient in bleach, sodium hypochlorite.
• Microcyn is broad spectrum and rapidly antimicrobial, effective against viruses, fungi and spores via unique mechanism of action.
• Biocompatible and as safe as saline.Biocompatible and Non-Toxic
• Clinically, Microcyn is a biocompatible wound irrigant that is stable, non-toxic, non-cytotoxic, and non-irritating with antimicrobial properties.
• Microcyn is very efficacious at levels of free available chlorine (FAC) below the point at which toxicity begins.

Microcyn® Professional Dental Products

EndoGenix Endocyn Irrigant
16.9 oz (500 ml) with Sling Label for Hanging and Venting Spike Rubber Cap
In-Office Use
• Irrigant in hanging bottle.
• FDA cleared.

OroGenix Oral Hygiene Rinse with Microcyn
• 16.9 oz (500 ml) with Dispensing Cup
At-Home Care
• Oral hygiene rinse.

OroGenix Tooth Gel
4 oz with Squirt Cap
At-Home Care
• Non-fluoride tooth gel for brushing and oral care.






Hypochlorous Acid (HOCI) and the Human Inflammatory Response

• In phagocytosis, HOCI is present in the phagosome at about 300 ppm.
• HOCI at concentrations on the order of 300 ppm been shown to be safe in irrigants - wound cleaners
• Neutrophils can chemically sense pathogens in their immediate environment via biochemical signaling methods and direct contact, resulting in phagocytosis of the pathogen.
• The pathogen is engulfed into an intracellular structure (phagosome), followed by biochemical reactions within the phagosome including the intracellular production of HOCI.
• Rapid pathogen destruction ensues secondary to pathogen cell wall destruction and essential internal protein disruption.
• Pathogen debris is ejected from the neitophil along with some HOCI

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